WASHINGTON, May 21 (Xinhua) — U.S. Secretary of State Mike Pompeo said on Monday here that Iran will suffer the toughest sanctions in history from the United States if it does not change the current course.

Pompeo on Monday called for a new nuclear agreement with Iran following President Donald Trump’s withdrawal from the 2015 nuclear deal. He says the Trump administration prefers for it to be a treaty that is ratified by Congress.

Pompeo is laying out an onerous list of 12 “basic requirements” demands on Iran that he says should be included. He says Iran must “stop enrichment” of uranium and never preprocess plutonium. Iran must also allow nuclear “unqualified access to all sites throughout the country.”

Pompeo says Iran must also “release all U.S. citizens,” end support for Houthi rebels in Yemen, “withdraw all forces” from Syria and stop threatening Israel.